Micromechanical sensors based on conformational change of proteins

Xin Yang; Koutilya R. Buchapudi; Hongyan Gao; Xiaohe Xu; Hai-Feng Ji

doi:10.1117/12.776180

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30 April 2008 Micromechanical sensors based on conformational change of proteins

Xin Yang, Koutilya R. Buchapudi, Hongyan Gao, Xiaohe Xu, Hai-Feng Ji

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Proceedings Volume 6959, Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II; 69590N (2008) https://doi.org/10.1117/12.776180
Event: SPIE Defense and Security Symposium, 2008, Orlando, Florida, United States

Abstract

Microcantilevers (MCLs) hold a position as a cost-effective and highly sensitive sensor platform for medical diagnostics, environmental, and fast throughput analysis. One of recently focus in this technology is the development of biosensors based on the conformational change of proteins on MCL surfaces. The surface stress changes due to conformational change of the proteins upon interaction with specific analytes are promising as transducers of chemical information. We will discuss our recent results on several biosensors due to conformational change of proteins. The proteins include glucose oxidase (GOx), organophosphorus hydrolyses (OPH), Calmodulin (CaM), and Horseradish peroxidase (HRP).

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Xin Yang, Koutilya R. Buchapudi, Hongyan Gao, Xiaohe Xu, and Hai-Feng Ji "Micromechanical sensors based on conformational change of proteins", Proc. SPIE 6959, Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II, 69590N (30 April 2008); https://doi.org/10.1117/12.776180

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