Experimental results of chemical recording using thermally sensitive liposomes

Maria E. Tanner; Elizabeth A. Vasievich; Jonathan M. Protz

doi:10.1117/12.783803

30 April 2008 Experimental results of chemical recording using thermally sensitive liposomes

Maria E. Tanner, Elizabeth A. Vasievich, Jonathan M. Protz

Proceedings Volume 6959, Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II; 69590S (2008) https://doi.org/10.1117/12.783803
Event: SPIE Defense and Security Symposium, 2008, Orlando, Florida, United States

Abstract

A new generation of inertial measurement technology is being developed enabling a 10-micron particle to be "aware" of its geospatial location and respond to this information. The proposed approach combines an inertially-sensitive nano-structure or nano fluid/structure system with a nano-sized chemical reactor that functions as an analog computer. By using chemistry to perform the necessary computational steps in our device, it is possible to overcome traditional limitations on device size. The proposed nanodevice utilizes mechanical sensing and chemical recording to record the time history of various state variables. Using a micro-track containing regions of different temperatures and thermally-sensitive liposomes (TSL), a range of accelerations can be recorded and the position determined. Through careful design, TSL can be developed that have unique transition temperatures and each class of TSL will contain a unique DNA sequence that serves as an identifier. Acceleration can be detected through buoyancy-driven convection. As the liposomes travel to regions of warmer temperature, they will release their contents at the recording site, thus documenting the acceleration. This paper will present the initial proof-of-concept experimental results achieved from chemical recording of the state variable temperature. The experiment focuses on the liposome release of the DNA due to temperature variations and subsequent binding and recording of the time history. These results prove the feasibility of this method of sensing and recording of the history of state variables.

Citation Download Citation

Maria E. Tanner, Elizabeth A. Vasievich, and Jonathan M. Protz "Experimental results of chemical recording using thermally sensitive liposomes", Proc. SPIE 6959, Micro (MEMS) and Nanotechnologies for Space, Defense, and Security II, 69590S (30 April 2008); https://doi.org/10.1117/12.783803

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KEYWORDS

Mechanical sensors

Thin films

Data analysis

Microfluidics

Temperature metrology

Acquisition tracking and pointing

Analog electronics

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