Preprocessing and analysis of microarray images from integrated lensless bio-photonic sensors

Jesús Angulo; Christian Lajaunie; Michel Bilodeau; Lucio Martinelli; Françoise Le Boulaire; Fernand Meyer

doi:10.1117/12.781377

6 May 2008 Preprocessing and analysis of microarray images from integrated lensless bio-photonic sensors

Jesús Angulo, Christian Lajaunie, Michel Bilodeau, Lucio Martinelli, Françoise Le Boulaire, Fernand Meyer

Proceedings Volume 7000, Optical and Digital Image Processing; 700014 (2008) https://doi.org/10.1117/12.781377
Event: SPIE Photonics Europe, 2008, Strasbourg, France

Abstract

A new integrated lensless bio-photonic sensors is being developed. It replaces the ordinary slide supporting the DNA spots, and the complex, large and expensive hybridisation and the scanner reading system, by a sandwich of well defined chemical and optical layers grafted onto a CCD sensor. The upper layer of the new biochip performs the biological function. Due to the architecture of the biochip leading to a lensless imaging of the spots directly on the sensor pixels, the images produced will have novel characteristics beyond the analysis capacity of reading software packages of microarray analysis. In this framework, specific image processing and statistical data analysis algorithms have been developed in order to assess and to quantify these images.

Citation Download Citation

Jesús Angulo, Christian Lajaunie, Michel Bilodeau, Lucio Martinelli, Françoise Le Boulaire, and Fernand Meyer "Preprocessing and analysis of microarray images from integrated lensless bio-photonic sensors", Proc. SPIE 7000, Optical and Digital Image Processing, 700014 (6 May 2008); https://doi.org/10.1117/12.781377

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