Plasmonic nanohole arrays for real-time multiplex biosensing

Antoine Lesuffleur; Hyungsoon Im; Nathan C. Lindquist; Kwan Seop Lim; Sang-Hyun Oh

doi:10.1117/12.794299

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29 August 2008 Plasmonic nanohole arrays for real-time multiplex biosensing

Antoine Lesuffleur, Hyungsoon Im, Nathan C. Lindquist, Kwan Seop Lim, Sang-Hyun Oh

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Proceedings Volume 7035, Biosensing; 703504 (2008) https://doi.org/10.1117/12.794299
Event: NanoScience + Engineering, 2008, San Diego, California, United States

Abstract

Large-scale studies of biomolecular interactions required for proteome-level investigations can benefit from a new class of emerging surface plasmon resonance (SPR) sensors: nanohole arrays and surface plasmon (SP) enhanced optical transmission. In this paper we present a real-time, label-free multiplex SPR imaging sensor in a microarray format. The system presented is built around a low-cost microscope with laser illumination, integrated with microfluidics. The specific binding kinetics of biotin and streptavidin are measured from several sensing elements simultaneously, demonstrating the feasibility of using nanohole arrays as a high-throughput SPR microarray sensor.

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Antoine Lesuffleur, Hyungsoon Im, Nathan C. Lindquist, Kwan Seop Lim, and Sang-Hyun Oh "Plasmonic nanohole arrays for real-time multiplex biosensing", Proc. SPIE 7035, Biosensing, 703504 (29 August 2008); https://doi.org/10.1117/12.794299

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