DNA sequence-based comparative studies between non-extremophile and extremophile organisms with implications in exobiology

Todd Holden; P. Marchese; G. Tremberger Jr.; E. Cheung; R. Subramaniam; R. Sullivan; P. Schneider; A. Flamholz; D. Lieberman; T. Cheung

doi:10.1117/12.801269

28 August 2008 DNA sequence-based comparative studies between non-extremophile and extremophile organisms with implications in exobiology

Todd Holden, P. Marchese, G. Tremberger Jr., E. Cheung, R. Subramaniam, R. Sullivan, P. Schneider, A. Flamholz, D. Lieberman, T. Cheung

Author Affiliations +

Proceedings Volume 7097, Instruments, Methods, and Missions for Astrobiology XI; 70970Q (2008) https://doi.org/10.1117/12.801269
Event: Optical Engineering + Applications, 2008, San Diego, California, United States

Abstract

We have characterized function related DNA sequences of various organisms using informatics techniques, including fractal dimension calculation, nucleotide and multi-nucleotide statistics, and sequence fluctuation analysis. Our analysis shows trends which differentiate extremophile from non-extremophile organisms, which could be reproduced in extraterrestrial life. Among the systems studied are radiation repair genes, genes involved in thermal shocks, and genes involved in drug resistance. We also evaluate sequence level changes that have occurred during short term evolution (several thousand generations) under extreme conditions.

Citation Download Citation

Todd Holden, P. Marchese, G. Tremberger Jr., E. Cheung, R. Subramaniam, R. Sullivan, P. Schneider, A. Flamholz, D. Lieberman, and T. Cheung "DNA sequence-based comparative studies between non-extremophile and extremophile organisms with implications in exobiology", Proc. SPIE 7097, Instruments, Methods, and Missions for Astrobiology XI, 70970Q (28 August 2008); https://doi.org/10.1117/12.801269

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available