Frontal brain activation during a working memory task: a time-domain fNIRS study

E. Molteni; G. Baselli; A. M. Bianchi; M. Caffini; D. Contini; L. Spinelli; A. Torricelli; S. Cerutti; R. Cubeddu

doi:10.1117/12.808972

23 February 2009 Frontal brain activation during a working memory task: a time-domain fNIRS study

E. Molteni, G. Baselli, A. M. Bianchi, M. Caffini, D. Contini, L. Spinelli, A. Torricelli, S. Cerutti, R. Cubeddu

Proceedings Volume 7161, Photonic Therapeutics and Diagnostics V; 71613N (2009) https://doi.org/10.1117/12.808972
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

We evaluated frontal brain activation during a working memory task with graded levels of difficulty in a group of 19 healthy subjects, by means of time-resolved fNIRS technique. Brain activation was computed, and was then separated into a "block-related" and a "tonic" components. Load-related increases of blood oxygenation were studied for the four different levels of task difficulty. Generalized Linear Models were applied to the data in order to explore the metabolic processes occurring during the mental effort and, possibly, their involvement in short term memorization. Results attest the presence of a persistent attentional-related metabolic activity, superimposed to a task-related mnemonic contribution. Moreover, a systemic component probably deriving from the extra-cerebral capillary bed was detected.

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E. Molteni, G. Baselli, A. M. Bianchi, M. Caffini, D. Contini, L. Spinelli, A. Torricelli, S. Cerutti, and R. Cubeddu "Frontal brain activation during a working memory task: a time-domain fNIRS study", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71613N (23 February 2009); https://doi.org/10.1117/12.808972

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