Epithelial cancer detection by oblique-incidence optical spectroscopy

Alejandro Garcia-Uribe; Karthik C. Balareddy; Jun Zou; Kenneth K. Wang M.D.; Madeleine Duvic; Lihong V. Wang

doi:10.1117/12.808576

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23 February 2009 Epithelial cancer detection by oblique-incidence optical spectroscopy

Alejandro Garcia-Uribe, Karthik C. Balareddy, Jun Zou, Kenneth K. Wang M.D., Madeleine Duvic, Lihong V. Wang

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Proceedings Volume 7169, Advanced Biomedical and Clinical Diagnostic Systems VII; 71690A (2009) https://doi.org/10.1117/12.808576
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

This paper presents a study on non-invasive detection of two common epithelial cancers (skin and esophagus) based on oblique incidence diffuse reflectance spectroscopy (OIDRS). An OIDRS measurement system, which combines fiber optics and MEMS technologies, was developed. In our pilot studies, a total number of 137 cases have been measured in-vivo for skin cancer detection and a total number of 20 biopsy samples have been measured ex-vivo for esophageal cancer detection. To automatically differentiate the cancerous cases from benign ones, a statistical software classification program was also developed. An overall classification accuracy of 90% and 100% has been achieved for skin and esophageal cancer classification, respectively.

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Alejandro Garcia-Uribe, Karthik C. Balareddy, Jun Zou, Kenneth K. Wang M.D., Madeleine Duvic, and Lihong V. Wang "Epithelial cancer detection by oblique-incidence optical spectroscopy", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71690A (23 February 2009); https://doi.org/10.1117/12.808576

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