3D optical contrast-recovery in MR guided diffuse optical spectroscopy

Colin Carpenter; Subhadra Srinivasan; Brian Pogue; Keith D. Paulsen

doi:10.1117/12.808943

23 February 2009 3D optical contrast-recovery in MR guided diffuse optical spectroscopy

Colin Carpenter, Subhadra Srinivasan, Brian Pogue, Keith D. Paulsen

Proceedings Volume 7174, Optical Tomography and Spectroscopy of Tissue VIII; 71740G (2009) https://doi.org/10.1117/12.808943
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

It is well known that diffuse optical tomography (DOT) has limited spatial resolution, and sufficient contrast recovery is limited to lesions greater than ~6 mm[1]. However, with the addition of multimodality methods that combine high spatial resolution imaging, such as MRI, it has been shown that quantification and feature recovery improves[2]. However, it is not known how well MRg-DOS will perform with characterizing small lesions in 3D. These limits need to be established in order to determine the practical limitations of optical imaging. This paper investigates the contrast resolution limits of 3 dimensional MRg-DOS. Short irregular inclusions of various diameters are added to a homogeneous background. Two case studies are presented which represent these limiting situations.

Citation Download Citation

Colin Carpenter, Subhadra Srinivasan, Brian Pogue, and Keith D. Paulsen "3D optical contrast-recovery in MR guided diffuse optical spectroscopy", Proc. SPIE 7174, Optical Tomography and Spectroscopy of Tissue VIII, 71740G (23 February 2009); https://doi.org/10.1117/12.808943

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