A study on optical modulation signal and tissue displacement in ultrasound modulated optical tomography

Rui Li; Daniel S. Elson; Chris Dunsby; Robert Eckersley; Meng-Xing Tang

doi:10.1117/12.809035

12 February 2009 A study on optical modulation signal and tissue displacement in ultrasound modulated optical tomography

Rui Li, Daniel S. Elson, Chris Dunsby, Robert Eckersley, Meng-Xing Tang

Author Affiliations +

Proceedings Volume 7177, Photons Plus Ultrasound: Imaging and Sensing 2009; 71772E (2009) https://doi.org/10.1117/12.809035
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Ultrasound modulated optical tomography (UOT) is a hybrid technique which combines optical contrast with ultrasound resolution and has shown some potential for early cancer detection, functional and molecular imaging. However, one current problem with this technique is the weak optical modulation signal strength and consequently low Signal-to-Noise Ratio (SNR). In this study, the effect of increasing the amplitude of the ultrasound induced particle displacement on the UOT signal is investigated using a Monte Carlo simulation tool. The simulation software was validated against those reported in the literature and good agreement was achieved. The simulated amplitude of particle displacement was varied from 0.1 to 500nm . The results showed a significant increase in UOT signal with particle displacement for low displacements, followed by saturation when displacement increased beyond a certain level. Further simulations were performed to investigate the saturation by changing the optical wavelength from 400nm to 600nm . The results show that the UOT signal saturates at lower particle displacements for smaller wavelengths. This suggests that the phase variations along a photon path can be large enough to cause cancellation as particle displacement increases. This study is part of ongoing efforts to improve the SNR of UOT through using the large particle displacements created by high amplitude ultrasound and radiation forces.

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Rui Li, Daniel S. Elson, Chris Dunsby, Robert Eckersley, and Meng-Xing Tang "A study on optical modulation signal and tissue displacement in ultrasound modulated optical tomography", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71772E (12 February 2009); https://doi.org/10.1117/12.809035

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