Iron oxide nanoparticle hyperthermia and chemotherapy cancer treatment

A. A. Petryk; A. J. Giustini; P. Ryan; R. R. Strawbridge; P. J. Hoopes

doi:10.1117/12.810024

23 February 2009 Iron oxide nanoparticle hyperthermia and chemotherapy cancer treatment

A. A. Petryk, A. J. Giustini, P. Ryan, R. R. Strawbridge, P. J. Hoopes

Proceedings Volume 7181, Energy-based Treatment of Tissue and Assessment V; 71810N (2009) https://doi.org/10.1117/12.810024
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The benefit of combining hyperthermia and chemotherapy to treat cancer is well established. However, combined therapy has not yet achieved standard of care status. The reasons are numerous and varied, however the lack of significantly greater tumor cell sensitivity to heat (as compared to normal cells) and the inability to deliver heat to the tumor in a precise manner have been major factors. Iron oxide nanoparticle (IONP) hyperthermia, alone and combined with other modalities, offers a new direction in hyperthermia cancer therapy via improved tumor targeting and an improved therapeutic ratio. Our preliminary studies have demonstrated tumor cell cytotoxicity (in vitro and in vivo) with IONP heat and cisplatinum (CDDP) doses lower than those necessary when using conventional heating techniques or cisplatinum alone. Ongoing studies suggest such treatment could be further improved through the use of targeted nanoparticles.

Citation Download Citation

A. A. Petryk, A. J. Giustini, P. Ryan, R. R. Strawbridge, and P. J. Hoopes "Iron oxide nanoparticle hyperthermia and chemotherapy cancer treatment", Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810N (23 February 2009); https://doi.org/10.1117/12.810024

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available