An intrauterine ultrasound applicator for targeted delivery of thermal therapy in conjunction with HDR brachytherapy to the cervix

Jeffery H. Wootton; Titania Juang; Jean Pouliot; I-Chow Joe Hsu; Chris J. Diederich

doi:10.1117/12.808343

23 February 2009 An intrauterine ultrasound applicator for targeted delivery of thermal therapy in conjunction with HDR brachytherapy to the cervix

Jeffery H. Wootton, Titania Juang, Jean Pouliot, I-Chow Joe Hsu, Chris J. Diederich

Author Affiliations +

Proceedings Volume 7181, Energy-based Treatment of Tissue and Assessment V; 71810T (2009) https://doi.org/10.1117/12.808343
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

An intracavitary hyperthermia applicator for targeted heat delivery to the cervix was developed based on a linear array of sectored tubular ultrasound transducers that provides truly 3-D heating control (angular and along the length). A central conduit can incorporate an HDR source for sequential or simultaneous delivery of heat and radiation. Hyperthermia treatment volumes were determined from brachytherapy treatment planning data and used as a basis for biothermal simulations analyzing the effects of device parameters, tissue properties, and catheter materials on heating patterns. Devices were then developed with 1-3 elements at 6.5-8 MHz with 90-180° sectors and a 15-35 mm heating length, housed within a 6-mm diameter water-cooled PET catheter. Directional heating from sectored transducers could extend lateral penetration of therapeutic heating (41°C) >2 cm while maintaining rectum and bladder temperatures within 12 mm below thermal damage thresholds. Imaging artifacts were evaluated with standard CT, cone beam CT, and MR images. MR thermal imaging was used to demonstrate shaping of heating profiles in axial and coronal slices with artifact <2 mm from the device. The impact of the high-Z applicator materials on the HDR dose distribution was assessed using a well-type ionization chamber and was found to be less than 6% attenuation, which can readily be accounted for with treatment planning software. The intrauterine ultrasound device has demonstrated potential for 3-D conformal heating of clinical tumors in the delivery of targeted hyperthermia in conjunction with brachytherapy to the cervix.

Citation Download Citation

Jeffery H. Wootton, Titania Juang, Jean Pouliot, I-Chow Joe Hsu, and Chris J. Diederich "An intrauterine ultrasound applicator for targeted delivery of thermal therapy in conjunction with HDR brachytherapy to the cervix", Proc. SPIE 7181, Energy-based Treatment of Tissue and Assessment V, 71810T (23 February 2009); https://doi.org/10.1117/12.808343

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available