Effect of UV irradiation on the apoptosis and necrosis of Jurkat cells using UV LEDs

Shunko A. Inada; Hiroshi Amano; Isamu Akasaki; Akimichi Morita; Keiko Kobayashi

doi:10.1117/12.809929

3 February 2009 Effect of UV irradiation on the apoptosis and necrosis of Jurkat cells using UV LEDs

Shunko A. Inada, Hiroshi Amano, Isamu Akasaki, Akimichi Morita, Keiko Kobayashi

Proceedings Volume 7231, Light-Emitting Diodes: Materials, Devices, and Applications for Solid State Lighting XIII; 72310J (2009) https://doi.org/10.1117/12.809929
Event: SPIE OPTO: Integrated Optoelectronic Devices, 2009, San Jose, California, United States

Abstract

Phototherapy is a very effective method for treating most of the incurable skin diseases. A fluorescent light bulb is used as a conventional UV light source for this type of therapy. However, infrared radiation from the light source sometimes causes serious problems on patient's health. In addition, the normal part of the skin is irradiated when a large fluorescent light bulb is used. Moreover, a conventional UV irradiation system is heavy and has a short lifetime and a high electrical power consumption. Therefore, a new UV light source for solving the problems of phototherapy is required. To realize low-power-consumption, lightweight and long-lifetime systems, group III nitride-based UV-A1 light-emitting diodes (LEDs) were investigated. We examined the UV LED irradiation of Jurkat cell, which is a tumor cell and more sensitive to UV light than a healthy cell. The numbers of apoptotic and necrotic cells were confirmed to be the same using a UV LED and a conventional lamp system. The UV LED showed the possibility of realizing a new UV light source for phototherapy.

Citation Download Citation

Shunko A. Inada, Hiroshi Amano, Isamu Akasaki, Akimichi Morita, and Keiko Kobayashi "Effect of UV irradiation on the apoptosis and necrosis of Jurkat cells using UV LEDs", Proc. SPIE 7231, Light-Emitting Diodes: Materials, Devices, and Applications for Solid State Lighting XIII, 72310J (3 February 2009); https://doi.org/10.1117/12.809929

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