Pre-reconstruction three-material decomposition in dual-energy CT

Lifeng Yu; Xin Liu; Cynthia H. McCollough

doi:10.1117/12.813686

13 March 2009 Pre-reconstruction three-material decomposition in dual-energy CT

Lifeng Yu, Xin Liu, Cynthia H. McCollough

Proceedings Volume 7258, Medical Imaging 2009: Physics of Medical Imaging; 72583V (2009) https://doi.org/10.1117/12.813686
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

It is of clinical interest to quantify the concentration of materials in a three-component mixture with known chemical compositions, such as bone-mineral density (BMD) in a trabecular bone composed of calcium hydroxyappitite (CaHA), yellow- and red-marrow, and iron content in the liver composed of soft tissue, fat, and iron. Both pre- and postreconstruction dual-energy CT methods have been used to achieve this goal. The pre-reconstruction method is more accurate due to the elimination of beam-hardening artifacts. After obtaining the equivalent densities of the two basis materials, however, it is unclear how to accurately estimate the concentration of each material in the presence of the third material in the mixture. In this work, we present a pre-reconstruction three-material decomposition method in dualenergy CT to quantify the concentration of each material in a three-component mixture with known chemical compositions. This method employs a specific physical constraint on the equivalent densities of the two basis materials obtained from the conventional basis-material decomposition. We evaluated this method using simulation studies on two types of three-component mixtures: bone-water-fat and Iron-water-CaHA. The results demonstrated that an accurate estimation of the concentration for each material can be achieved with the proposed method.

Citation Download Citation

Lifeng Yu, Xin Liu, and Cynthia H. McCollough "Pre-reconstruction three-material decomposition in dual-energy CT", Proc. SPIE 7258, Medical Imaging 2009: Physics of Medical Imaging, 72583V (13 March 2009); https://doi.org/10.1117/12.813686

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available