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The nonlinear mechanical behavior of tissues that undergo large deformations, e.g. the breast, is characterized by
hyperelastic parameters. These parameters take into account both types of nonlinearities: tissue intrinsic nonlinearity and
geometric nonlinearity. Elastography technique capable of tissue hyperelastic parameter reconstruction has important
clinical applications such as cancer diagnosis and interventional procedure planning. In this study we report our progress
on the development of constrained reconstruction technique of breast tissue hyperelastic parameters [1]. The extension of
this work is twofold: the inclusion of the popular Veronda-Westmann hyperelastic model and using a novel technique for
tissue displacement tracking. This tracking technique is based on the Horn-Schunck optical flow method [2]. The
objective of this paper is to validate the numerical analysis performed in [1] by phantom experiment. For this purpose, a
PVA (Polyvinyl Alcohol) phantom that consists of three tissue types was constructed and tested. PVA exhibits nonlinear
mechanical behavior and has been recently used for tissue mimicking purposes. Reconstruction results showed that it is
feasible to find the relative hyperelastic parameters of the tissue with acceptable accuracy. The error reported for the
relative parameter reconstruction was less than 20%, which may be sufficient for cancer diagnosis purposes.
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Hatef Mehrabian, Abbas Samani, "Constrained hyperelastic parameters reconstruction of PVA (Polyvinyl Alcohol) phantom undergoing large deformation," Proc. SPIE 7261, Medical Imaging 2009: Visualization, Image-Guided Procedures, and Modeling, 72612G (13 March 2009); https://doi.org/10.1117/12.813871