Hyperpolarized 129Xe magnetic resonance imaging of a rat model of transient ischemic stroke

Ronn P. Walvick; Birgul Bastan; Austin Reno; Joey Mansour; Yanping Sun; Xin Zhou; Mary Mazzanti; Marc Fisher; Christopher H. Sotak; Mitchell S. Albert

doi:10.1117/12.812344

27 February 2009 Hyperpolarized ¹²⁹Xe magnetic resonance imaging of a rat model of transient ischemic stroke

Ronn P. Walvick, Birgul Bastan, Austin Reno, Joey Mansour, Yanping Sun, Xin Zhou, Mary Mazzanti, Marc Fisher, Christopher H. Sotak, Mitchell S. Albert

Author Affiliations +

Proceedings Volume 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging; 726209 (2009) https://doi.org/10.1117/12.812344
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Ischemic stroke accounts for nearly 80% of all stroke cases. Although proton diffusion and perfusion magnetic resonance imaging (MRI) are the gold standards in ischemic stroke diagnostics, the use of hyperpolarized ¹²⁹Xe MRI has a potential role to contribute to the diagnostic picture. The highly lipophilic hyperpolarized ¹²⁹Xe can be non-invasively delivered via inhalation into the lungs where it is dissolved into the blood and delivered to other organs such as the brain. As such, we expect hyperpolarized ¹²⁹Xe to act as a perfusion tracer which will result in a signal deficit in areas of blood deprived tissue. In this work, we present imaging results from an animal model of transient ischemic stroke characterized through ¹²⁹Xe MRI. In this model, a suture is used to occlude the middle cerebral artery (MCA) in the rat brain, thus causing an ischemic event. After a period of MCA occlusion, the suture can then be removed to reperfuse the ischemic area. During the ischemic phase of the stroke, a signal void was observed in the MCA territory; which was subsequently restored by normal ¹²⁹Xe MRI signal once perfusion was reinstated. Further, a higher resolution one-dimensional chemical shift image shows a sharp signal drop in the area of ischemia. Validation of ischemic damage was shown through both proton diffusion-weighted MRI (DWI) and by 2,3,5-triphenyltetrazoliumchloride (TTC) staining. The results show the potential of ¹²⁹Xe to act as a perfusion tracer; information that may add to the diagnostic and prognostic utility of the clinical picture of stroke.

Citation Download Citation

Ronn P. Walvick, Birgul Bastan, Austin Reno, Joey Mansour, Yanping Sun, Xin Zhou, Mary Mazzanti, Marc Fisher, Christopher H. Sotak, and Mitchell S. Albert "Hyperpolarized ¹²⁹Xe magnetic resonance imaging of a rat model of transient ischemic stroke", Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 726209 (27 February 2009); https://doi.org/10.1117/12.812344

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Magnetic resonance imaging

Brain

Tissues

Blood

Polarization

Ischemic stroke

Xenon

Show All Keywords

Keywords/Phrases

Search In:

Publication Years