3D registration of micro PET-CT for measurable correlates of dyspeptic symptoms in mice

Jon Camp; Kathryn Simpson; Michael R. Bardsley; Laura N. Popko; David L. Young; Bradley J. Kemp; Val Lowe; Tamas Ordog; Richard Robb M.D.

doi:10.1117/12.811408

27 February 2009 3D registration of micro PET-CT for measurable correlates of dyspeptic symptoms in mice

Jon Camp, Kathryn Simpson, Michael R. Bardsley, Laura N. Popko, David L. Young, Bradley J. Kemp, Val Lowe, Tamas Ordog, Richard Robb M.D.

Author Affiliations +

Proceedings Volume 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging; 72620Z (2009) https://doi.org/10.1117/12.811408
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Patients with chronic calorie insufficiency commonly suffer from upper gastrointestinal dysfunction and consequent dyspeptic symptoms, which may interfere with their nutritional rehabilitation. To investigate the relationship between gastric dysfunction and feeding behavior, we exposed mice to chronic caloric restriction and demonstrated gastric motor abnormalities in them. Gastric dysmotility is typically associated with dyspeptic symptoms but sensations cannot be directly assessed in animal models. Therefore, as an initial step toward establishing measurable correlates of postprandial symptoms in small animals, we have attempted to characterize central responses to food intake by positron emission tomography-computerized microtomography (PET-CT) in normal and calorically restricted mice. Animals consumed a standard test meal after an overnight fast before receiving 2-deoxy-2[¹⁸F]fluoro-D-glucose tracer. The same mice were also scanned in the fasting state on a separate day. We were able to bring the fed and fasting PET volume images into spatial registration with each other and with an MR-derived atlas of the mouse brain, so that the differences in uptake between the two states could be mapped quantitatively against the neuroanatomic regions of the atlas. Our approach is suitable for studying the effects of gastric dysmotilities on central responses to feeding.

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Jon Camp, Kathryn Simpson, Michael R. Bardsley, Laura N. Popko, David L. Young, Bradley J. Kemp, Val Lowe, Tamas Ordog, and Richard Robb M.D. "3D registration of micro PET-CT for measurable correlates of dyspeptic symptoms in mice", Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 72620Z (27 February 2009); https://doi.org/10.1117/12.811408

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KEYWORDS

Image registration

Positron emission tomography

Computed tomography

Brain

Visualization

Magnetic resonance imaging

Neuroimaging

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