Combinational method for focal brain activation detection using MEG signal

Mehdi Rajabioun; Abbas Babajani-Feremi; Hamid Soltanian-Zadeh

doi:10.1117/12.813876

27 February 2009 Combinational method for focal brain activation detection using MEG signal

Mehdi Rajabioun, Abbas Babajani-Feremi, Hamid Soltanian-Zadeh

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Proceedings Volume 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging; 726220 (2009) https://doi.org/10.1117/12.813876
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Magnetoencephalography (MEG) is a neuroimaging technique for brain activation detection. This technique does not provide a unique solution due to ill-posedness of its inverse solution. Several methods are proposed to improve the MEG inverse solution. Minimum Norm (MN) is a simple method whose solution is distributed and biased toward the superficial sources. In addition, its solution is sensitive to the noise. Several methods are proposed to improve performance of the MN method. In this paper, we propose a method whose solution is less sensitive to the noise and spatially unbiased toward the superficial sources. Control of focal solution properties is achieved by specifying a parameter in the proposed method. Performance of the proposed method is compared to others using simulation studies consisting of single and multiple dipole sources as well as an extended source model. Proposed method has superior performance compared to non-iterative methods. Its performance is similar to the iterative methods but its computational load is lower.

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Mehdi Rajabioun, Abbas Babajani-Feremi, and Hamid Soltanian-Zadeh "Combinational method for focal brain activation detection using MEG signal", Proc. SPIE 7262, Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, 726220 (27 February 2009); https://doi.org/10.1117/12.813876

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KEYWORDS

Magnetoencephalography

Signal to noise ratio

Signal detection

Sensors

Iterative methods

Brain

Brain activation

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