The spectrum character of photoreaction of Hypocrellin A and cysteine

Jucheng Zhang; Wei Liu; Ying Li; Pei Zhang; Zhongzhou Yi; Yong Min; Zhaolong Huang; Lihua Yao; Haiju Lu

doi:10.1117/12.821301

6 March 2009 The spectrum character of photoreaction of Hypocrellin A and cysteine

Jucheng Zhang, Wei Liu, Ying Li, Pei Zhang, Zhongzhou Yi, Yong Min, Zhaolong Huang, Lihua Yao, Haiju Lu

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 72800R (2009) https://doi.org/10.1117/12.821301
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

In the current work, Hypocrellin A (HA) is one of the nature photosensitizer was recognized by researchers, and it used as a probe to research the molecular recognition and interaction with protein, the work suggested the HA can as the medicine to treat some disease. This paper study the spectrum character of photoreaction of Hypocrellin A and cysteine in different pH value, the spectrum show an isosbestic point at 495nm, and the absorption peak at 478nm was red-shifted to about 500nm. The result suggested the HA can react with cysteine in this condition, and farther illuminated the cysteine residue may is one of the target of the interaction of HA or HB with protein.

Citation Download Citation

Jucheng Zhang, Wei Liu, Ying Li, Pei Zhang, Zhongzhou Yi, Yong Min, Zhaolong Huang, Lihua Yao, and Haiju Lu "The spectrum character of photoreaction of Hypocrellin A and cysteine", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72800R (6 March 2009); https://doi.org/10.1117/12.821301

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