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6 March 2009 Optoelectronic monitoring of neural activity
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Neural activity is a process of induction and propagation of neural excitability. Clarifying the mechanism of neural activity is one of the basic goals of modern brain science. The calcium ion, a second messenger in the brain, plays key roles in neuronal signaling pathways. To detect electrophysiology signals basing on membrane potential change of neurons and fluorescence signals basing on calcium dynamics and fluorescence labeling technique is critical for understanding neuronal signaling. In this research, a random access two-photon fluorescence microscope system basing on acousto-optic deflectors was used to monitor calcium fluorescence signals of neurons, combining a HEKA patch clamp to detect neuronal electrophysiology synchronously. Results showed that the optoelectronic method to monitor the firing of action potential at 50 Hz has single action potential resolution.
© (2009) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Xiuli Liu, Tingwei Quan, and Wei Zhou "Optoelectronic monitoring of neural activity", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72802P (6 March 2009);

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