Photonic metallic nanostructures in photodynamic therapy

Rodica-Mariana Ion; R. C. Fierascu; Irina Dumitriu

doi:10.1117/12.823687

7 January 2009 Photonic metallic nanostructures in photodynamic therapy

Rodica-Mariana Ion, R. C. Fierascu, Irina Dumitriu

Proceedings Volume 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV; 729723 (2009) https://doi.org/10.1117/12.823687
Event: Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 2008, Constanta, Romania

Abstract

Plasmons are resonant modes that involve the interaction between free charges and light. Nanoparticle-based photonic explorers have been developed for photodynamic therapy (PDT). PDT has been widely used in both oncological (e.g., tumors) and nononcological (e.g., age-related macular degeneration, localized infection, and nonmalignant skin conditions) applications. Three primary components are involved in PDT: light, a photosensitizing drug, and oxygen. The photosensitizer adsorbs light energy, which it then transfers to molecular oxygen to create an activated form of oxygen called singlet oxygen. The singlet oxygen is a cytotoxic agent and reacts rapidly with cellular components to cause damage that ultimately leads to cell death and tumor destruction. The changed topography of the film surface after deposition is caused by a local material transport and a material separation between formed particles (probably AgNO₃) and an embedding polymer matrix as chitosan. This paper focuses on the current use of injectable in situ Au/(Ag)/chitosan hydrogels in cancer photodynamic treatment. Formulation protocols for their cytotoxic properties, their effect on cell growth in vitro and inhibition of tumor growth in vivo using mouse models, are discussed.

Citation Download Citation

Rodica-Mariana Ion, R. C. Fierascu, and Irina Dumitriu "Photonic metallic nanostructures in photodynamic therapy", Proc. SPIE 7297, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IV, 729723 (7 January 2009); https://doi.org/10.1117/12.823687

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