Rapid, ultrasensitive detection of microorganisms based on interferometry and lab-on-a-chip nanotechnology

Aurel Ymeti; Paul H. J. Nederkoorn; Alma Dudia; Vinod Subramaniam; Johannes S. Kanger

doi:10.1117/12.818466

5 May 2009 Rapid, ultrasensitive detection of microorganisms based on interferometry and lab-on-a-chip nanotechnology

Aurel Ymeti, Paul H. J. Nederkoorn, Alma Dudia, Vinod Subramaniam, Johannes S. Kanger

Proceedings Volume 7306, Optics and Photonics in Global Homeland Security V and Biometric Technology for Human Identification VI; 73060J (2009) https://doi.org/10.1117/12.818466
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

Future viral outbreaks are a major threat to societal and economic development throughout the world. A rapid, sensitive, and easy-to-use test for viral infections is essential to prevent and to control such viral pandemics. Furthermore, a compact, portable device is potentially very useful in remote or developing regions without easy access to sophisticated laboratory facilities. We have developed a rapid, ultrasensitive sensor that could be used in a handheld device to detect various viruses and measure their concentration. The essential innovation in this technique is the combination of an integrated optical interferometric sensor with antibody-antigen recognition approaches to yield a very sensitive, very rapid test for virus detection. The sensor is able to spot the herpes virus at concentrations of just 850 particles per milliliter under physiological conditions. The sensitivity of the sensor approaches detection of a single virus particle, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics. The sensor's detection principle can be extended to any biological target such as bacteria, cells and proteins and for which there are specific antibodies. The nature of the sensor enables multiplexed detection of several analytes at the same time.

Citation Download Citation

Aurel Ymeti, Paul H. J. Nederkoorn, Alma Dudia, Vinod Subramaniam, and Johannes S. Kanger "Rapid, ultrasensitive detection of microorganisms based on interferometry and lab-on-a-chip nanotechnology", Proc. SPIE 7306, Optics and Photonics in Global Homeland Security V and Biometric Technology for Human Identification VI, 73060J (5 May 2009); https://doi.org/10.1117/12.818466

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