eSensor: an electrochemical detection-based DNA microarray technology enabling sample-to-answer molecular diagnostics

Robin H. Liu; Mathew Longiaru

doi:10.1117/12.819476

5 May 2009 eSensor: an electrochemical detection-based DNA microarray technology enabling sample-to-answer molecular diagnostics

Robin H. Liu, Mathew Longiaru

Author Affiliations +

Proceedings Volume 7306, Optics and Photonics in Global Homeland Security V and Biometric Technology for Human Identification VI; 73060M (2009) https://doi.org/10.1117/12.819476
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

DNA microarrays are becoming a widespread tool used in life science and drug screening due to its many benefits of miniaturization and integration. Microarrays permit a highly multiplexed DNA analysis. Recently, the development of new detection methods and simplified methodologies has rapidly expanded the use of microarray technologies from predominantly gene expression analysis into the arena of diagnostics. Osmetech's eSensor^® is an electrochemical detection platform based on a low-to- medium density DNA hybridization array on a cost-effective printed circuit board substrate. eSensor^® has been cleared by FDA for Warfarin sensitivity test and Cystic Fibrosis Carrier Detection. Other genetic-based diagnostic and infectious disease detection tests are under development. The eSensor^® platform eliminates the need for an expensive laser-based optical system and fluorescent reagents. It allows one to perform hybridization and detection in a single and small instrument without any fluidic processing and handling. Furthermore, the eSensor^® platform is readily adaptable to on-chip sample-to-answer genetic analyses using microfluidics technology. The eSensor^® platform provides a cost-effective solution to direct sample-to-answer genetic analysis, and thus have a potential impact in the fields of point-of-care genetic analysis, environmental testing, and biological warfare agent detection.

Citation Download Citation

Robin H. Liu and Mathew Longiaru "eSensor: an electrochemical detection-based DNA microarray technology enabling sample-to-answer molecular diagnostics", Proc. SPIE 7306, Optics and Photonics in Global Homeland Security V and Biometric Technology for Human Identification VI, 73060M (5 May 2009); https://doi.org/10.1117/12.819476

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