Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography

Yuting Lin; William C. Barber; Jan S. Iwanczyk; Einar Nygard; Nail Malakov; Neal E. Hartsough; Thulasi Gandhi; Werner W. Roeck; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/12.831719

1 July 2009 Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography

Yuting Lin, William C. Barber, Jan S. Iwanczyk, Einar Nygard, Nail Malakov, Neal E. Hartsough, Thulasi Gandhi, Werner W. Roeck, Orhan Nalcioglu, Gultekin Gulsen

Author Affiliations +

Proceedings Volume 7370, Molecular Imaging II; 73700G (2009) https://doi.org/10.1117/12.831719
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

We demonstrate the feasibility of using a dual-modality fluorescence and x-ray computed tomography (CT) system for quantitative molecular imaging with phantom studies. A CCD based non-contact FT system, which can take measurements from multiple views was built. High-resolution X-Ray CT was used to obtain structural information from the phantom. A 3.6 mm diameter fluorescence inclusion was deeply embedded in the heterogeneous optical background. The results demonstrated that the fluorophore concentration can only be obtained accurately when guided by the a priori information provided by the x-ray CT.

Citation Download Citation

Yuting Lin, William C. Barber, Jan S. Iwanczyk, Einar Nygard, Nail Malakov, Neal E. Hartsough, Thulasi Gandhi, Werner W. Roeck, Orhan Nalcioglu, and Gultekin Gulsen "Dual-modality molecular imaging for small animals using fluorescence and x-ray computed tomography", Proc. SPIE 7370, Molecular Imaging II, 73700G (1 July 2009); https://doi.org/10.1117/12.831719

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE