Photodynamic therapy of cervical intraepithelial neoplasia using hexaminolevulinate and methylaminolevulinate

Philipp Soergel; Ismini Staboulidou; Herrmann Hertel; Cordula Schippert; Peter Hillemanns

doi:10.1117/12.824462

13 July 2009 Photodynamic therapy of cervical intraepithelial neoplasia using hexaminolevulinate and methylaminolevulinate

Philipp Soergel, Ismini Staboulidou, Herrmann Hertel, Cordula Schippert, Peter Hillemanns

Author Affiliations +

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738031 (2009) https://doi.org/10.1117/12.824462
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Cervical intraepithelial neoplasia (CIN) is the precursor of invasive cervical cancer. Previous studies indicated that photodynamic therapy (PDT) represents an effective treatment modality in CIN. In 28 patients with CIN 1 - 3, 1 - 2 cycles of PDT were conducted using hexaminolevulinate (HAL) or methylaminolevulinate (MAL) and a special light delivery system. After 6 months, biopsies were obtained to assess response. The overall response rate for complete or partial response was 65%. Photodynamic therapy using new ALA esters is effective and may offer unique advantages in the therapy of CIN.

Citation Download Citation

Philipp Soergel, Ismini Staboulidou, Herrmann Hertel, Cordula Schippert, and Peter Hillemanns "Photodynamic therapy of cervical intraepithelial neoplasia using hexaminolevulinate and methylaminolevulinate", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738031 (13 July 2009); https://doi.org/10.1117/12.824462

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