Meta-analysis of five photodisinfection clinical trials for periodontitis

Roger C. Andersen; Nicolas G. Loebel; Dane M. Andersen

doi:10.1117/12.823567

13 July 2009 Meta-analysis of five photodisinfection clinical trials for periodontitis

Roger C. Andersen, Nicolas G. Loebel, Dane M. Andersen

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73804K (2009) https://doi.org/10.1117/12.823567
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Photodynamic therapy(PDT) has been demonstrated to effectively kill human periopathogens in vitro. To evaluate the efficacy of PDT in vivo a series of clinical trials was carried out in multiple centers and populations. Clinical parameters including clinical attachment level, pocket probing depth and bleeding on probing were all evaluated. All groups received the standard of care, scaling and root planing, and the treatment group additionally received a single treatment of PDT. Of the total 309 patients and over 40,000 pockets treated in these 5 trials it was determined that photodynamic therapy provided a statistically significant improvement in clinical parameters over scaling and root planing alone.

Citation Download Citation

Roger C. Andersen, Nicolas G. Loebel, and Dane M. Andersen "Meta-analysis of five photodisinfection clinical trials for periodontitis", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73804K (13 July 2009); https://doi.org/10.1117/12.823567

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