Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections

Ulysses W. Sallum; Xiang Zheng; Sarika Verma; Tayyaba Hasan

doi:10.1117/12.828202

13 July 2009 Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections

Ulysses W. Sallum, Xiang Zheng, Sarika Verma, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 73806R (2009) https://doi.org/10.1117/12.828202
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

β-lactamase enzyme-activated photosensitizer (β-LEAP). We aim to exploit drug resistance mechanisms to selectively release photosensitizers (PSs) for a specific photodynamic antimicrobial effect and reduced host tissue damage. Consequently, the fluorescence emission intensity of the PSs increases and allows for the detection of enzyme activity. In this work we sought to evaluate β-LEAP for use as a sensitive molecular probe. We have reported the enzyme specific antibacterial action of β-LEAP. Here we report the use of β-LEAP for the rapid functional definition of a β-lactamase.

Citation Download Citation

Ulysses W. Sallum, Xiang Zheng, Sarika Verma, and Tayyaba Hasan "Exploiting bacterial drug resistance: a single construct for the diagnosis and treatment of drug resistant infections", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 73806R (13 July 2009); https://doi.org/10.1117/12.828202

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