Generation of singlet oxygen and other radical species by quantum dot and carbon dot nanosensitizers

Roman Generalov; Ingeborg Lie Christensen; Wei Chen; Ya-Ping Sun; Solveig Kristensen; Petras Juzenas

doi:10.1117/12.830353

13 July 2009 Generation of singlet oxygen and other radical species by quantum dot and carbon dot nanosensitizers

Roman Generalov, Ingeborg Lie Christensen, Wei Chen, Ya-Ping Sun, Solveig Kristensen, Petras Juzenas

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738072 (2009) https://doi.org/10.1117/12.830353
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Medicinal applications of luminescent semiconductor quantum dots are of growing interest. In spite of the fact that their fabrication and imaging applications have been extensively investigated for the last decade, very little is documented on photodynamic action of quantum dots. In this study we demonstrate generation of singlet oxygen and other radical species upon exposure of quantum dots to blue light and therapeutic red light. Extent of radical production can be readily modified by antioxidants. Lay and scientific communities are two sites concerning potential hazards and enthusiastic applications of nanotechnology. Synthesis of quantum dots composed of less toxic materials is of great interest. A new candidate is a ubiquitous element carbon, which on nanoscale exhibits strong photoluminescence.

Citation Download Citation

Roman Generalov, Ingeborg Lie Christensen, Wei Chen, Ya-Ping Sun, Solveig Kristensen, and Petras Juzenas "Generation of singlet oxygen and other radical species by quantum dot and carbon dot nanosensitizers", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738072 (13 July 2009); https://doi.org/10.1117/12.830353

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