Characterization of microfluidic systems with Doppler optical coherence tomography

L. Carrion; E. Hamel; A. Leblanc-Hotte; C. Boudoux; O. Guenat; R. Maciejko

doi:10.1117/12.839798

4 August 2009 Characterization of microfluidic systems with Doppler optical coherence tomography

L. Carrion, E. Hamel, A. Leblanc-Hotte, C. Boudoux, O. Guenat, R. Maciejko

Proceedings Volume 7386, Photonics North 2009; 73860B (2009) https://doi.org/10.1117/12.839798
Event: Photonics North 2009, 2009, Quebec, Canada

Abstract

Doppler Optical Coherence Tomography (DOCT) is a biomedical imaging technique that allows simultaneous structural imaging and flow monitoring inside biological tissues and materials with spatial resolution in the micrometer scale. It has recently been applied to the characterization of microfluidic systems. Structural and flow imaging of novel microfluidics platforms for cytotoxicologic applications were obtained with a real-time, Near Infrared Spectral Domain DOCT system. Characteristics such as flow homogeneity in the chamber, which is one of the most important parameters for cell culture, are investigated. OCT and DOCT images were used to monitor flow inside a specific platform that is based on microchannel division for a better flow homogeneity. In particular, the evolution of flow profile at the transition between the microchannel structure and the chamber is studied.

Citation Download Citation

L. Carrion, E. Hamel, A. Leblanc-Hotte, C. Boudoux, O. Guenat, and R. Maciejko "Characterization of microfluidic systems with Doppler optical coherence tomography", Proc. SPIE 7386, Photonics North 2009, 73860B (4 August 2009); https://doi.org/10.1117/12.839798

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