Methods for nanoparticle labeling of ricin and effect on toxicity

Alastair W. Wark; Jun Yu; Christopher D. Lindsay; Paola Nativo; Duncan Graham

doi:10.1117/12.833545

17 September 2009 Methods for nanoparticle labeling of ricin and effect on toxicity

Alastair W. Wark, Jun Yu, Christopher D. Lindsay, Paola Nativo, Duncan Graham

Proceedings Volume 7486, Optics and Photonics for Counterterrorism and Crime Fighting V; 748604 (2009) https://doi.org/10.1117/12.833545
Event: SPIE Security + Defence, 2009, Berlin, Germany

Abstract

The unique optical properties associated with nanostructured materials that support the excitation of surface plasmons offer many new opportunities for the enhanced optical investigation of biological materials that pose a security threat. In particular, ricin is considered a significant bioterrorism risk due to its high toxicity combined with its ready availability as a byproduct in castor oil production. Therefore, the development of optical techniques capable of rapid on-site toxin detection with high molecular specificity and sensitivity continues to be of significant importance. Furthermore, understanding of the ricin cell entry and intracellular pathways remains poor due to a lack of suitable bioanalytical techniques. Initial work aimed at simultaneously tackling both these issues is described where different approaches for the nanoparticle labeling of ricin are investigated along with changes in ricin toxicity associated with the labeling process.

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Alastair W. Wark, Jun Yu, Christopher D. Lindsay, Paola Nativo, and Duncan Graham "Methods for nanoparticle labeling of ricin and effect on toxicity", Proc. SPIE 7486, Optics and Photonics for Counterterrorism and Crime Fighting V, 748604 (17 September 2009); https://doi.org/10.1117/12.833545

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KEYWORDS

Nanoparticles

Toxicity

Gold

Proteins

Transmission electron microscopy

Molecules

Particles

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