An automatic method for measurement of vertebral bone density based on QCT without an external reference phantom

Kai Zhao; Xiao-guang Pan; Yu-yue Zou; Yan Kang

doi:10.1117/12.830955

30 October 2009 An automatic method for measurement of vertebral bone density based on QCT without an external reference phantom

Kai Zhao, Xiao-guang Pan, Yu-yue Zou, Yan Kang

Author Affiliations +

Proceedings Volume 7497, MIPPR 2009: Medical Imaging, Parallel Processing of Images, and Optimization Techniques; 74972I (2009) https://doi.org/10.1117/12.830955
Event: Sixth International Symposium on Multispectral Image Processing and Pattern Recognition, 2009, Yichang, China

Abstract

Purpose: We developed an automatic method for measurement of vertebral bone density based on QCT with the use of internal references(muscle and subcutaneous fat) instead of traditional external phantom. Methods: The automatic multistep approach starts with segmentation of periosteal and endosteal surfaces of spine to define ellipse ROI in cancellous bone followed by segmentation of muscle and subcutaneous fat in the spine image and a subsequent calculation of bone mineral density in ellipse ROI and segmentation trabecular and cortical bone ROI using muscle and subcutaneous fat as internal references. The segmentation approach used a hybrid region-growing method which used local adaptive threshold and morphological operation. Results: We conducted with-phantom and without-phantom measurements by using 94 clinical cases. The doctor manually defined the ellipse ROI in the with-phantom measurement. As for the without-phantom measurement, we use our method to automatically gain the BMD. The Interaclass Correlation Coefficient (ICC) is 0.93. We removed the points whose muscle and fat values are 2 times deviated from the standard deviation. And the calibrated ICC value is 0.999. Conclusion: The without-phantom measurement method is not fit for the patients whose muscle and fat are seriously deviated from the average value. The without-phantom measurement method proposed in this paper can automatically measure the BMD of spine. By accurately segmenting cortical bone and trabecular bone, determining ROI and removing inappropriate data, it is proved that the BMD measurement result by this method is highly consistent with that by with-phantom method.

Citation Download Citation

Kai Zhao, Xiao-guang Pan, Yu-yue Zou, and Yan Kang "An automatic method for measurement of vertebral bone density based on QCT without an external reference phantom", Proc. SPIE 7497, MIPPR 2009: Medical Imaging, Parallel Processing of Images, and Optimization Techniques, 74972I (30 October 2009); https://doi.org/10.1117/12.830955

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available