In vivo tumor imaging in mice with near-infrared: low density lipoprotein conjugates

Xinyang Chen; Dawei Deng; Fei Liu; Hui Li; Zhiyu Qian; Yueqing Gu

doi:10.1117/12.846899

28 October 2009 In vivo tumor imaging in mice with near-infrared: low density lipoprotein conjugates

Xinyang Chen, Dawei Deng, Fei Liu, Hui Li, Zhiyu Qian, Yueqing Gu

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 75190P (2009) https://doi.org/10.1117/12.846899
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

Near-infrared (NIR) fluorescence imaging possesses many advantages as an in vivo non-invasive optical imaging modality for studying diseases in preclinical models. In this study, low density lipoprotein(LDL) fraction was quickly isolated from human plasma by modified heparin-citrate precipitation method and then conjugated to near infrared fluorescence dye ICG-Der-02 with excitation and emission wavelengths at 760nm and 830nm, respectively. The conjugates LDL-ICG-Der-02 were intravenously injected into the mice bearing different tumor models. And real time series fluorescence tumor images at different intervals of post-injection were in vivo acquired by a self-built NIR reflectance fluorescence imaging system. Results demonstrated that LDL-ICG-Der-02 conjugates could efficiently target to the tumor sites that over-expressed LDL receptors and could be completely eliminated at last.

Citation Download Citation

Xinyang Chen, Dawei Deng, Fei Liu, Hui Li, Zhiyu Qian, and Yueqing Gu "In vivo tumor imaging in mice with near-infrared: low density lipoprotein conjugates", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 75190P (28 October 2009); https://doi.org/10.1117/12.846899

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KEYWORDS

Tumors

Luminescence

Near infrared

In vivo imaging

Particles

Plasma

Imaging systems

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