A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers

Chetan A. Patil; Harish Krishnamoorthi; Darrel L. Ellis; Ton G. van Leeuwen; Anita Mahadevan-Jansen

doi:10.1117/12.843708

2 March 2010 A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers

Chetan A. Patil, Harish Krishnamoorthi, Darrel L. Ellis, Ton G. van Leeuwen, Anita Mahadevan-Jansen

Proceedings Volume 7548, Photonic Therapeutics and Diagnostics VI; 75480L (2010) https://doi.org/10.1117/12.843708
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical instrument for morphological and biochemical characterization of skin cancers with combined RS-OCT. The portable instrument utilizes independent RS and OCT system backbones, and is integrated in a common clinical probe. The potential of the probe for cancer diagnosis is demonstrated on malignant and non-malignant lesions.

Citation Download Citation

Chetan A. Patil, Harish Krishnamoorthi, Darrel L. Ellis, Ton G. van Leeuwen, and Anita Mahadevan-Jansen "A clinical probe for combined Raman spectroscopy-optical coherence tomography (RS-OCT) of the skin cancers", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75480L (2 March 2010); https://doi.org/10.1117/12.843708

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