Spectroscopic evaluation of photodynamic therapy of the intraperitoneal cavity

Jarod C. Finlay; Julia L. Sandell; Timothy C. Zhu; Robert Lewis; Keith A. Cengel; Stephen M. Hahn

doi:10.1117/12.843184

2 March 2010 Spectroscopic evaluation of photodynamic therapy of the intraperitoneal cavity

Jarod C. Finlay, Julia L. Sandell, Timothy C. Zhu, Robert Lewis, Keith A. Cengel, Stephen M. Hahn

Proceedings Volume 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX; 755109 (2010) https://doi.org/10.1117/12.843184
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We present the results of spectroscopic measurements of diffuse reflectance and fluorescence before and after photodynamic therapy of healthy canine peritoneal cavity. Animals were treated intra-operatively after iv injection of the benzoporphyrin derivative (BPD). The small bowel was treated using a uniform light field projected by a microlens-tipped fiber. The cavity was then filled with scattering medium and the remaining organs were treated using a moving diffuser. Diffuse reflectance and fluorescence measurements were made using a multi-fiber optical probe positioned on the surface of various tissues within the cavity before and after illumination. The measured data were analyzed to quantify hemoglobin concentration and oxygenation and sensitizer concentration.

Citation Download Citation

Jarod C. Finlay, Julia L. Sandell, Timothy C. Zhu, Robert Lewis, Keith A. Cengel, and Stephen M. Hahn "Spectroscopic evaluation of photodynamic therapy of the intraperitoneal cavity", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 755109 (2 March 2010); https://doi.org/10.1117/12.843184

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available