Novel visible light activated type 1 photosensitizers

Raghavan Rajagopalan; Amolkumar Karwa; Amruta R. Poreddy; Przemyslaw M. Lusiak; Raghoottama S. Pandurangi; Gary L. Cantrell; Richard B. Dorshow

doi:10.1117/12.844970

2 March 2010 Novel visible light activated type 1 photosensitizers

Raghavan Rajagopalan, Amolkumar Karwa, Amruta R. Poreddy, Przemyslaw M. Lusiak, Raghoottama S. Pandurangi, Gary L. Cantrell, Richard B. Dorshow

Author Affiliations +

Proceedings Volume 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX; 75510R (2010) https://doi.org/10.1117/12.844970
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Photodynamic therapy of tumors involving Type 2 photosenstizers has been conspicuously successful, but the Type 1 process, in contrast, has not received much attention despite its considerable potential. Accordingly, several classes of molecules containing fragile bonds such as azido (-N=N=N), azo (-N=N-), and oxaza (-N-O-) functional groups that produce reactive intermediates such as radicals and nitrenes upon photoexcitation with visible light were prepared and tested for cell viability using U397 leukemia cell line. The cells were incubated with the photosensitizer at various concentrations, and were illuminated for 5, 10, and 20 minutes. The results show that all the photosensitizers caused cell death compared to the controls when exposed to both the photosensitizers and light.

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Raghavan Rajagopalan, Amolkumar Karwa, Amruta R. Poreddy, Przemyslaw M. Lusiak, Raghoottama S. Pandurangi, Gary L. Cantrell, and Richard B. Dorshow "Novel visible light activated type 1 photosensitizers", Proc. SPIE 7551, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX, 75510R (2 March 2010); https://doi.org/10.1117/12.844970

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KEYWORDS

Photodynamic therapy

Visible radiation

Leukemia

Oxygen

Control systems

Phototherapy

Tumors

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