Review of technology development and clinical trials of transcranial laser therapy for acute ischemic stroke treatment

Brian E. Catanzaro; Jackson Streeter M.D.; Luis de Taboada

doi:10.1117/12.842043

25 February 2010 Review of technology development and clinical trials of transcranial laser therapy for acute ischemic stroke treatment

Brian E. Catanzaro, Jackson Streeter M.D., Luis de Taboada

Author Affiliations +

Proceedings Volume 7552, Mechanisms for Low-Light Therapy V; 75520J (2010) https://doi.org/10.1117/12.842043
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Stroke is the one of the leading causes of mortality in the United States, claiming 600,000 lives each year. Evidence suggests that near infrared (NIR) illumination has a beneficial effect on a variety of cells when these cells are exposed to adverse conditions. Among these conditions is the hypoxic state produced by acute ischemic stroke (AIS). To demonstrate the impact NIR Transcranial Laser Therapy (TLT) has on AIS in humans, a series of double blind, placebo controlled clinical trials were designed using the NeuroThera^(R) System (NTS). The NTS was designed and developed to treat subjects non-invasively using 808 nm NIR illumination. TLT, as it applies to stroke therapy, and the NTS will be described. The results of the two clinical trials: NeuroThera^(R) Safety and Efficacy Trial 1 (NEST-1) and NeuroThera^(R) Safety and Efficacy Trial 2 (NEST-2) will be reviewed and discussed.

Citation Download Citation

Brian E. Catanzaro, Jackson Streeter M.D., and Luis de Taboada "Review of technology development and clinical trials of transcranial laser therapy for acute ischemic stroke treatment", Proc. SPIE 7552, Mechanisms for Low-Light Therapy V, 75520J (25 February 2010); https://doi.org/10.1117/12.842043

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