Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)

Chao Zhou; Yihong Wang; Aaron D. Aguirre; Tsung-Han Tsai; David W. Cohen; James L. Connolly; James G. Fujimoto

doi:10.1117/12.843616

19 February 2010 Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)

Chao Zhou, Yihong Wang, Aaron D. Aguirre, Tsung-Han Tsai, David W. Cohen, James L. Connolly, James G. Fujimoto

Author Affiliations +

Proceedings Volume 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV; 755409 (2010) https://doi.org/10.1117/12.843616
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. Thirty four thyroid gland specimens were imaged from 17 patients, covering a spectrum of pathology, ranging from normal thyroid to neoplasia and benign disease. The integrated OCT and OCM imaging system allows seamlessly switching between low and high magnifications, in a way similar to traditional microscopy. Good correspondence was observed between optical images and histological sections. The results provide a basis for interpretation of future OCT and OCM images of the thyroid tissues and suggest the possibility of future in vivo evaluation of thyroid pathology.

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Chao Zhou, Yihong Wang, Aaron D. Aguirre, Tsung-Han Tsai, David W. Cohen, James L. Connolly, and James G. Fujimoto "Multiscale imaging of human thyroid pathologies using integrated optical coherence tomography (OCT) and optical coherence microscopy (OCM)", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 755409 (19 February 2010); https://doi.org/10.1117/12.843616

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