In situ optical property measurement in layered tissue: theoretical and experimental assessment of an unconstrained approach

Quanzeng Wang; T. Joshua Pfefer

doi:10.1117/12.842412

24 February 2010 In situ optical property measurement in layered tissue: theoretical and experimental assessment of an unconstrained approach

Quanzeng Wang, T. Joshua Pfefer

Author Affiliations +

Proceedings Volume 7556, Design and Quality for Biomedical Technologies III; 75560J (2010) https://doi.org/10.1117/12.842412
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We have investigated a potential technique based on spatially resolved reflectance to determine optical properties (OPs) in two-layer turbid media. Reflectance from two-layer tissue was simulated for a wide range of OP combinations (μ_a = 1-22.5, μs' = 5-42.5 cm^-1) using a condensed Monte Carlo (MC) model and utilized to train neural network (NN) inverse models. Experimental data from two-layer tissue phantoms with top layer thicknesses (D) ranging from 0.22 to 0.66 mm were collected at three UV-Vis wavelengths. Estimation accuracy was compared to simulated results with added noise. The mean error in experimental determination of μa ranged from 1.5 to 5.9 cm^-1 and mean error for μs' ranged from 2.1 to 12.1 cm^-1 as a function of D. Although numerous realistic challenges remain, this initial experimental study of an unconstrained two-layer diffuse reflectance based OP estimation approach provides support that such a technique has a strong potential to provide accurate in situ measurements in layered tissues.

Citation Download Citation

Quanzeng Wang and T. Joshua Pfefer "In situ optical property measurement in layered tissue: theoretical and experimental assessment of an unconstrained approach", Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560J (24 February 2010); https://doi.org/10.1117/12.842412

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Reflectivity

Tissues

Data modeling

Tissue optics

Monte Carlo methods

Optical fibers

Optical properties

Show All Keywords

Keywords/Phrases

Search In:

Publication Years