Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements

Sarah Ruderman; Valentina Stoyneva; Andrew J. Gomes; Jeremy D. Rogers; Vadim Backman

doi:10.1117/12.842857

23 February 2010 Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements

Sarah Ruderman, Valentina Stoyneva, Andrew J. Gomes, Jeremy D. Rogers, Vadim Backman

Author Affiliations +

Proceedings Volume 7556, Design and Quality for Biomedical Technologies III; 75560K (2010) https://doi.org/10.1117/12.842857
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Noninvasive and real-time analysis of tissue properties, in particular, the quantitative assessment of blood content and light scattering properties of mucosa is useful in a wide variety of applications. However, the nature of interactions between contact fiber-optic probes and the tissue surface presents a challenging problem with respect to the variability of in vivo measurements, for example affects due to variations in the pressure and angle of the probe tip on the tissue surface. Previously, pressure and angle effects have been investigated for other modalities (i.e. diffuse reflectance and Raman spectroscopy). We present an evaluation of this variability, as well as the length of time in contact with tissue for polarization-gated spectroscopy. The evaluation is based on the quantification of mucosal blood content at superficial depths (within 100 to 200 microns of tissue surface) for in vivo measurements of oral mucosa. Measurements are presented for different pressures, angles and time scales and the variability due to these factors is assessed.

Citation Download Citation

Sarah Ruderman, Valentina Stoyneva, Andrew J. Gomes, Jeremy D. Rogers, and Vadim Backman "Assessment of pressure, angle, and temporal effects on polarization-gated spectroscopic probe measurements", Proc. SPIE 7556, Design and Quality for Biomedical Technologies III, 75560K (23 February 2010); https://doi.org/10.1117/12.842857

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available