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23 February 2010 Integrated catheter for intravascular ultrasound and photoacoustic imaging
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The vulnerability of atherosclerotic plaques that are formed in the arterial walls due to atherosclerosis depends on both their distribution and composition. The distribution of the plaques can be imaged using an intravascular ultrasound (IVUS) imaging which is a clinically approved minimally-invasive method. The recently introduced intravascular photoacoustic (IVPA) imaging may be used to obtain the necessary information about the composition of the plaques. Previous studies using excised rabbit arteries have demonstrated that the combined IVUS/IVPA imaging may simultaneously provide the morphology and functional information of plaques. However, for in-vivo IVUS/IVPA imaging, an integrated IVUS/IVPA imaging catheter capable both of delivering light into a vessel lumen with consequent detection of photoacoustic transients and of probing the arterial walls in pulse-echo mode is required. In the current study, an advanced prototype of the integrated IVUS/IVPA imaging catheter based on a 40-MHz single-element ultrasound transducer and a 600-μm-core single optical fiber is introduced. Unlike previously reported prototypes, the current integrated IVUS/IVPA imaging catheter is capable of cross-sectional imaging of vessel walls via mechanical rotation of the catheter. The performance of the integrated IVUS/IVPA catheter was evaluated in tissue-mimicking phantoms with and without the presence of blood in a lumen. The results of our study suggest that the approach used to develop integrated IVUS/IVPA imaging catheter can be successfully translated to the clinical environment for in-vivo combined IVUS/IVPA imaging.
© (2010) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Andrei B. Karpiouk, Bo Wang, and Stanislav Y. Emelianov "Integrated catheter for intravascular ultrasound and photoacoustic imaging", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756408 (23 February 2010);

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