In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli

Christopher Favazza; Konstantin Maslov; Lynn Cornelius; Lihong V. Wang

doi:10.1117/12.841975

23 February 2010 In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli

Christopher Favazza, Konstantin Maslov, Lynn Cornelius, Lihong V. Wang

Author Affiliations +

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 75640Z (2010) https://doi.org/10.1117/12.841975
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We report results of two in vivo functional human imaging experiments using photoacoustic microscopy. In Experiment 1, the hemodynamic response to an ischemic event was measured. The palm of a volunteer was imaged and a single cross-section was monitored while periodic arterial occlusions were administered using a blood pressure cuff wrapped around the upper arm and inflated to ~280 mmHg. Significant relative decreases in oxygen saturation (sO₂) and total hemoglobin (HbT) were observed during periods of ischemia. Upon release of the occlusion, significant relative increases in sO2 and HbT due to post-occlusive reactive hyperemia were recorded. Experiment 2 explored the vascular response to a local, external thermal stimulus. Thermal hyperemia is a common physiological phenomenon and thermoregulation function in which blood flow to the skin is increased to more efficiently exchange heat with the ambient environment. The forearm of a volunteer was imaged and a single cross-section was monitored while the imaged surface was exposed to an elevated temperature of ~46°C. Due to thermal hyperemia, relative increases in sO₂ and HbT were measured as the temperature of the surface was raised. These results may contribute as clinically relevant measures of vascular functioning for detection and assessment of vascular related diseases.

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Christopher Favazza, Konstantin Maslov, Lynn Cornelius, and Lihong V. Wang "In vivo functional human imaging using photoacoustic microscopy: response to ischemic and thermal stimuli", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 75640Z (23 February 2010); https://doi.org/10.1117/12.841975

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