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23 February 2010 Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography
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For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) non-invasively and in real time. The PAT system, based on a 512-element full-ring array with cylindrical focusing, received the PA signal primarily from a slice of about 2 mm thickness. This system can provide not only high resolution brain vasculature images but also hemodynamic functional images. We recorded the wash-in process of a photoacoustic contrast agent in a mouse brain in real time. Our results demonstrated that PAT is a powerful imaging modality to study real-time small animal neurofunctional activities that cause changes in hemodynamics.
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Changhui Li, Andres Aquirre, John Gamelin, Anastasios Maurudis, Quing Zhu, and Lihong V. Wang "Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756427 (23 February 2010);

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