Laser electrospray mass spectrometry of adsorbed molecules at atmospheric pressure

John J. Brady; Elizabeth J. Judge; Kuriakose Simon; Robert J. Levis

doi:10.1117/12.842217

24 February 2010 Laser electrospray mass spectrometry of adsorbed molecules at atmospheric pressure

John J. Brady, Elizabeth J. Judge, Kuriakose Simon, Robert J. Levis

Proceedings Volume 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII; 75680R (2010) https://doi.org/10.1117/12.842217
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Atmospheric pressure mass analysis of solid phase biomolecules is performed using laser electrospray mass spectrometry (LEMS). A non-resonant femtosecond duration laser pulse vaporizes native samples at atmospheric pressure for subsequent electrospray ionization and transfer into a mass spectrometer. LEMS was used to detect a complex molecule (irinotecan HCl), a complex mixture (cold medicine formulation with active ingredients: acetaminophen, dextromethorphan HBr and doxylamine succinate), and a biological building block (deoxyguanosine) deposited on steel surfaces without a matrix molecule.

Citation Download Citation

John J. Brady, Elizabeth J. Judge, Kuriakose Simon, and Robert J. Levis "Laser electrospray mass spectrometry of adsorbed molecules at atmospheric pressure", Proc. SPIE 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII, 75680R (24 February 2010); https://doi.org/10.1117/12.842217

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