Oblique-incidence spatially resolved diffuse reflectance spectroscopic diagnosis of skin cancer

Alejandro Garcia-Uribe; Jun Zou; Tzu-Hsuan Chang; Madeleine Duvic; Victor Prieto; Lihong V. Wang

doi:10.1117/12.842781

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25 February 2010 Oblique-incidence spatially resolved diffuse reflectance spectroscopic diagnosis of skin cancer

Alejandro Garcia-Uribe, Jun Zou, Tzu-Hsuan Chang, Madeleine Duvic, Victor Prieto, Lihong V. Wang

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Proceedings Volume 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics; 75720L (2010) https://doi.org/10.1117/12.842781
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

This paper presents the use of spatially resolved oblique-incidence diffuse reflectance spectroscopy for skin cancer diagnosis. Spatio-spectral data from 166 pigmented skin lesions were collected for the wavelength range from 455 to 765 nm. A set of neural network based classifiers separates the pigmented malignant melanomas from the benign and dysplastic subgroups. A total of 110 lesions were used as the training set and 56 lesions were used as the testing set. This classifier performs with an overall 100% sensitivity and 92% specificity for the training set and 100% sensitivity and 88% specificity for the testing set. The second classifier was designed to separate the benign from the dysplastic subgroups. For the second classifier a total of 100 lesions were used as the training set and 51 lesions were used as the testing set. The overall classification rates were 94% and 88% for the training and testing sets respectively.

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Alejandro Garcia-Uribe, Jun Zou, Tzu-Hsuan Chang, Madeleine Duvic, Victor Prieto, and Lihong V. Wang "Oblique-incidence spatially resolved diffuse reflectance spectroscopic diagnosis of skin cancer", Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 75720L (25 February 2010); https://doi.org/10.1117/12.842781

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