Photo-driven nano-impellers and nanovalves for on-command drug release

Yuen A Lau; Daniel P. Ferris; Jeffrey I. Zink

doi:10.1117/12.841175

1 March 2010 Photo-driven nano-impellers and nanovalves for on-command drug release

Yuen A Lau, Daniel P. Ferris, Jeffrey I. Zink

Proceedings Volume 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII; 75740P (2010) https://doi.org/10.1117/12.841175
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Three types of photo-responsive nano-architectures -nano-gatekeepers, nanovalves and nanoimpellers- were synthesized based on azobenzene derivatives tethered in and on mesporous silica nanoparticles. The light responsive nature of these materials enables them to be externally controlled such that transport of the cargo molecules from mesopores can be regulated. In particular, nanoimpellers have shown to successfully release anti-cancer drug, camptothecin, upon photoactivation and ultimately led to cell apoptosis.

Citation Download Citation

Yuen A Lau, Daniel P. Ferris, and Jeffrey I. Zink "Photo-driven nano-impellers and nanovalves for on-command drug release", Proc. SPIE 7574, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VII, 75740P (1 March 2010); https://doi.org/10.1117/12.841175

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