Cellular uptake of conjugated InP quantum dots

Hicham Chibli; Lina Carlini; Kalonji Ntumba; Jay Nadeau

doi:10.1117/12.848942

17 February 2010 Cellular uptake of conjugated InP quantum dots

Hicham Chibli, Lina Carlini, Kalonji Ntumba, Jay Nadeau

Proceedings Volume 7575, Colloidal Quantum Dots for Biomedical Applications V; 75750T (2010) https://doi.org/10.1117/12.848942
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Indium phosphide (InP) nanocrystals show similar absorbance and emission spectra to CdTe quantum dots, but unlike particles containing cadmium, may potentially be used in in vivo applications. However, the particles are more challenging to make water-soluble, show broader emission spectra than most quantum dots, and their behavior in living cells is largely unknown. In this work we solubilize InP nanocrystals with simple thiols (mercaptopropionic acid) and conjugate them to the neurotransmitter dopamine or the protein transferrin. Degree of uptake and labeling patterns of QDs alone, QD-dopamine, and QD-transferrin are compared in different cell lines and toxicity is evaluated using the sulforhodamine B (SRB) assay.

Citation Download Citation

Hicham Chibli, Lina Carlini, Kalonji Ntumba, and Jay Nadeau "Cellular uptake of conjugated InP quantum dots", Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 75750T (17 February 2010); https://doi.org/10.1117/12.848942

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available