Radiation sensitivity enhancement in cells using high-Z nanoparticles

Nathan J. Withers; John B. Plumley; Brian A. Akins; Antonio C. Rivera; Gloria Medina; Gennady A. Smolyakov; Graham S. Timmins; Marek Osinski

doi:10.1117/12.848944

26 February 2010 Radiation sensitivity enhancement in cells using high-Z nanoparticles

Nathan J. Withers, John B. Plumley, Brian A. Akins, Antonio C. Rivera, Gloria Medina, Gennady A. Smolyakov, Graham S. Timmins, Marek Osinski

Author Affiliations +

Proceedings Volume 7575, Colloidal Quantum Dots for Biomedical Applications V; 75750Z (2010) https://doi.org/10.1117/12.848944
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Cerium-doped lanthanum fluoride colloidal nanocrystals offer a way to improve radiation therapy through the enhanced absorption of high-energy photons. Lanthanum fluoride nanocrystals doped with 10% cerium and capped with oleic acid were synthesized in anhydrous methanol as platelets 3-6 nm in diameter and 1-3 nm thick. The nanocrystals were characterized by transmission electron microscopy and photoluminescence spectroscopy. Previously synthesized lanthanum fluoride nanocrystals doped with 10% cerium and capped with hydroxyl were used in radiation dose enhancement experiments that involved an incoming gamma flux from a 137Cs source and a FOX assay to measure absorbed energy. Possibility for lanthanide ions to be released into solution under gamma irradiation and to interfere with the assay was shown after the results were compared with the outcome of a similar previous experiment with the Fricke dosimeter solution. Finally, increased cell mortality of S. cerevisiae under gamma irradiation was observed in the presence of hydroxyl-capped lanthanum fluoride nanocrystals in the solution.

Citation Download Citation

Nathan J. Withers, John B. Plumley, Brian A. Akins, Antonio C. Rivera, Gloria Medina, Gennady A. Smolyakov, Graham S. Timmins, and Marek Osinski "Radiation sensitivity enhancement in cells using high-Z nanoparticles", Proc. SPIE 7575, Colloidal Quantum Dots for Biomedical Applications V, 75750Z (26 February 2010); https://doi.org/10.1117/12.848944

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