Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery

Travis A. Pecorelli; Marcelle M. Dibrell; Zongxi Li; Courtney R. Thomas; Jeffrey I. Zink

doi:10.1117/12.841168

1 March 2010 Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery

Travis A. Pecorelli, Marcelle M. Dibrell, Zongxi Li, Courtney R. Thomas, Jeffrey I. Zink

Proceedings Volume 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II; 75760K (2010) https://doi.org/10.1117/12.841168
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Multifunctional silica nanoparticles provide a framework for the attachment of imaging and targeting agents for applications in spectroscopy, microscopy, and biology while simultaneously serving as supports for molecular machines for the controlled release of cargo. The deliberate placing of molecules or other nanoparticles within specific regions of the mesostructure or the surface of the nanoparticles allows for multiple modes of characterization and application. This review focuses on research related to fluorescence and spectroscopic imaging techniques, targeting strategies to increase particle uptake efficiency in cells, and on demand drug delivery regulated by molecular machines.

Citation Download Citation

Travis A. Pecorelli, Marcelle M. Dibrell, Zongxi Li, Courtney R. Thomas, and Jeffrey I. Zink "Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery", Proc. SPIE 7576, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II, 75760K (1 March 2010); https://doi.org/10.1117/12.841168

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