Imaging properties of gold nanoparticles: CT number dependence study

Shu-Ju Tu; Hui-Ling Hsieh; Tsi-Chian Chao

doi:10.1117/12.843887

22 March 2010 Imaging properties of gold nanoparticles: CT number dependence study

Shu-Ju Tu, Hui-Ling Hsieh, Tsi-Chian Chao

Author Affiliations +

Proceedings Volume 7622, Medical Imaging 2010: Physics of Medical Imaging; 76222R (2010) https://doi.org/10.1117/12.843887
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

In recent years, there has been a rapid research progress of molecular imaging technology. Many investigations in molecular imaging such as the nanoparticle applications in targeted drug delivery have been widely studied in several key small animal models. Various nanoparticles used as either the drug delivery carriers, imaging contrast mediums or target-specific therapeutic agents have established a novel research platform for biomedical related scientists and clinicians. Among these nanoparticles, gold nanoparticles have the unique non-toxic and stability properties. In this work, a commercially-available micro CT imaging system was used to specifically study the imaging properties for 15 nm spherical-shaped gold particles. Imaging properties were quantified by the CT numbers obtained from a series of photon energy levels in the micro CT scanner. We also compared the imaging results between gold nanoparticles and iodinated contrast medium to study the potential impact of gold nanoparticles served as the contrast agent.

Citation Download Citation

Shu-Ju Tu, Hui-Ling Hsieh, and Tsi-Chian Chao "Imaging properties of gold nanoparticles: CT number dependence study", Proc. SPIE 7622, Medical Imaging 2010: Physics of Medical Imaging, 76222R (22 March 2010); https://doi.org/10.1117/12.843887

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