Quantifying breast density with a cone-beam breast CT

Xinhua Li; Bob Liu

doi:10.1117/12.844369

23 March 2010 Quantifying breast density with a cone-beam breast CT

Xinhua Li, Bob Liu

Proceedings Volume 7622, Medical Imaging 2010: Physics of Medical Imaging; 762245 (2010) https://doi.org/10.1117/12.844369
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Volumetric breast density was evaluated using a simulated cone beam breast CT with 80 kVp. The breast was modeled as a cylinder with background tissue composition of 20% glandular and 80% adipose. Various objects with different sizes and tissue compositions were embedded. Ray-tracing algorithm was utilized to obtain projection images in a full rotation without considering scatter, beam hardening and imaging noise. Filtered backprojection was adopted for image reconstruction with high quality. Reconstructed images had flat profiles except at large cone angle of 8.6° to 10°. They were calibrated using known linear attenuation coefficients of two image contrast objects. A 3D mapping of tissue densities could be directly computed within 5% error. Tissue volumes were obtained by counting voxels in appropriate attenuation coefficient ranges. Results of contrast objects were consistent with true volumes within 10% error. However, cone angle artifact decreased pixel values, and a reduction algorithm was required for accurate tissue assessment at large cone angles. This study indicates the possibility of excellent quantitative breast density measurements and volume assessments with cone-beam breast CT.

Citation Download Citation

Xinhua Li and Bob Liu "Quantifying breast density with a cone-beam breast CT", Proc. SPIE 7622, Medical Imaging 2010: Physics of Medical Imaging, 762245 (23 March 2010); https://doi.org/10.1117/12.844369

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available