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9 March 2010Digital breast tomosynthesis: feasibility of automated detection of microcalcification clusters on projections views
We are developing a computer-aided detection (CAD) system to assist radiologists in detecting microcalcification
clusters in digital breast tomosynthesis (DBT). The purpose of this study is to investigate the feasibility of a 2D approach
using the projection-view (PV) images as input. In the first stage, automated detection of the microcalcification clusters
on the PVs is performed. In the second stage, the detected cluster candidates or the individual microcalcifications on the
PVs are back-projected to the 3D volume. The true clusters or microcalcifications will therefore converge at their focal
planes and ideally will result in higher cluster or microcalcification scores than the FPs. In the final step an analysis of
the back-projected cluster or microcalcification candidates is performed to differentiate the true and false clusters. In this
pilot study, a limited data set of 39 cases with biopsy proven microcalcification clusters (17 malignant, 22 benign) was
used. The DBT scans were obtained in both CC and MLO views using a GE GEN2 prototype system which acquires 21
PVs over a 60º arc in 3º increments. In the 78 DBT volumes, a total of 74 clusters (33 malignant clusters in 34 breasts
and 41 benign clusters in 44 breasts) were identified by an experienced radiologist. The computer detected 61%
(956/1554) of the clusters on the PVs from the 74 scans. After back-projection of the microcalcification candidates detected
on the individual PVs and excluding the first few PVs that had higher noise in back-projection stage, 84% (62/74) of the true
clusters were detected in the 3D volume. Study is underway to develop methods to reduce FPs and to compare this 2D
approach with 3D or combined 2D and 3D approaches.
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Lubomir M. Hadjiiski, Heang-Ping Chan, Jun Wei, Berkman Sahiner, Chuan Zhou, Mark A. Helvie, "Digital breast tomosynthesis: feasibility of automated detection of microcalcification clusters on projections views," Proc. SPIE 7624, Medical Imaging 2010: Computer-Aided Diagnosis, 76241F (9 March 2010); https://doi.org/10.1117/12.844627